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Image Search Results
Journal: Drug Metabolism and Disposition
Article Title: Impact of the transcription factor nuclear factor 1 B T>C polymorphism on clozapine metabolism in vivo and expression of intestinal transporters in vitro
doi: 10.1016/j.dmd.2025.100100
Figure Lengend Snippet: Effect of NFIB rs28379954 T>C diplotype on metabolic ratios in smoking patients adjusting for age, sex, and sampling time. The data are analyzed using linear mixed model. The figure displays the fold change (95% CIs) in NFIB CT carriers (heterozygous for the target allele) versus NFIB TT carriers (homozygous for the target allele). Significant effect was observed for the metabolic ratio of N -desmethylclozapine cysteine: DCL-CYS/DCL (fold change: 1.89; CI: 1.04–3.44; P = .0384). contains the effect estimates, fold changes, and 95% CIs of the rest of the metabolites. CI, confidence interval; DCL, N -desmethylclozapine; DCL-CYS/DCL, DCL-cysteinyl; NFIB, nuclear factor 1 B.
Article Snippet: A predesigned TaqMan-based
Techniques: Sampling
Journal: Drug Metabolism and Disposition
Article Title: Impact of the transcription factor nuclear factor 1 B T>C polymorphism on clozapine metabolism in vivo and expression of intestinal transporters in vitro
doi: 10.1016/j.dmd.2025.100100
Figure Lengend Snippet: Effect of NFIB rs28379954 T>C diplotype on metabolic ratios in nonsmoking patients adjusting for age, sex, and sampling time. The data are analyzed using linear mixed model. The figure displays the fold change (95% CIs) in NFIB CT carriers (heterozygous for the target allele) versus NFIB TT carriers (homozygous for the target allele). No significant effect was observed for the metabolic ratios of the 30 metabolites. contains the effect estimates, fold changes, and 95% CIs of all the metabolites. CI, confidence interval; NFIB, nuclear factor 1 B.
Article Snippet: A predesigned TaqMan-based
Techniques: Sampling